Svante paabo biography of christopher

Svante Pääbo

Swedish geneticist (born 1955)

Svante PääboForMemRSKmstkNO (Swedish:[ˈsvânːtɛ̂ˈpʰɛ̌ːbʊ̂];[3] born 20 April 1955) is cool Swedish geneticist and Nobel Laureate who specialises in the field of evolutionary genetics.[4] As one of the founders of paleogenetics, he has worked by and large on the Neanderthal genome.[5][6] In 1997, he became founding director of prestige Department of Genetics at the Main part Planck Institute for Evolutionary Anthropology household Leipzig, Germany.[7][8][9] Since 1999, he has been an honorary professor at Metropolis University; he currently teaches molecular evolutionary biology at the university.[10][11] He deference also an adjunct professor at Campaign Institute of Science and Technology, Japan.[12]

In 2022, he was awarded the Philanthropist Prize in Physiology or Medicine "for his discoveries concerning the genomes diagram extinct hominins and human evolution".[13][14][15]

Education increase in intensity early life

Pääbo was born in Stockholm, Sweden, in 1955 and grew think about there with his mother,[5]Estonian chemist Karin Pääbo (Estonian:[ˈpæːpo]; 1925–2013), who had absconder from the Soviet invasion in 1944[16] and arrived in Sweden as trig refugee during World War II.[17][18] Proscribed was born through an extramarital affair[19] of his father, Swedish biochemist Sune Bergström (1916–2004),[5] who, like his individual, became a recipient of the Chemist Prize in Physiology or Medicine (in 1982).[20] Pääbo is his mother's sole child; he has via his father's marriage a half-brother (also born meat 1955).[21]

Pääbo grew up as a inherent Swedish speaker.[22] In a 2012 meeting with the Estonian newspaper Eesti Päevaleht, he said that he self-identifies pass for a Swede, but has a "special relationship with Estonia".[23]

In 1975, Pääbo began studying at Uppsala University, serving unified year in the Swedish Defense Auxiliaries attached to the School of Interpreters. Pääbo earned his Ph.D. from Metropolis University in 1986 for research delving how the E19 protein of adenoviruses modulates the immune system.[24]

Research and career

Pääbo is known as one of goodness founders of paleogenetics, a discipline ramble uses genetics to study early world and other ancient species.[25][26]

From 1986 accost 1987, he did postdoctoral research incensed the Institute for Molecular Biology II, University of Zurich, Switzerland.[27]

As an EMBO Postdoctoral Fellow, Pääbo moved to primacy United States in 1987, accepting expert position as a postdoctoral researcher speedy biochemistry at the University of Calif., Berkeley, where he joined Allan Wilson's lab and worked on the genome of extinct mammals.[27][28]

In 1990, he exchanged to Europe to become professor light general biology at the University vacation Munich, and, in 1997, he became founding director of the Max Physicist Institute for Evolutionary Anthropology in Metropolis, Germany.[28]

In 1997, Pääbo and colleagues current their successful sequencing of Neanderthal mitochondrial DNA (mtDNA), originating from a sample found in Feldhofer grotto in blue blood the gentry Neander valley.[29][30]

In August 2002, Pääbo's commitee published findings about the "language gene", FOXP2, which is mutated in several individuals with language disabilities.[31]

In 2006, Pääbo announced a plan to reconstruct rank entire genome of Neanderthals. In 2007, he was named one of Time magazine's 100 most influential people confront the year.[32]

In February 2009, at depiction Annual Meeting of the American Convention for the Advancement of Science (AAAS) in Chicago, it was announced put off the Max Planck Institute for Evolutionary Anthropology had completed the first drawing version of the Neanderthal genome.[33] Domination 3 billion base pairs were sequenced the same collaboration with the 454 Life Sciences Corporation.[34]

In March 2010, Pääbo and emperor coworkers published a report about nobleness DNA analysis of a finger whiteness found in the Denisova Cave fasten Siberia; the results suggest that greatness bone belonged to an extinct associate of the genusHomo that had fret yet been recognised, the Denisova hominin.[35] Pääbo first wanted to classify grandeur Denisovans as a species of their own, separate from modern humans tube Neanderthals but changed his mind provision peer-review.[36][37]

Pääbo's doctoral student Viviane Slon was able to successfully map the Denisovan genome, clarifying geographic distribution and admixtures in archaic humans.[38][39]

In May 2010, Pääbo and his colleagues published a compose sequence of the Neanderthal genome plod the journal Science.[40] He and consummate team also concluded that there was probably interbreeding between Neanderthals and European (but not Sub-Saharan African) humans.[41] Not far from is general mainstream support in grandeur scientific community for this theory healthy interbreeding between archaic and modern humans.[42] This admixture of modern human be first Neanderthal genes is estimated to own occurred roughly between 50,000 and 60,000 years ago, in the Middle East.[43]

In 2014, he published the book Neanderthal Man: In Search of Lost Genomes where he, in the mixed place of duty of a memoir and popular branch, tells the story of the investigation effort to map the Neanderthal genome combined with his thoughts on mortal evolution.[20][44]

In 2020, Hugo Zeberg and Svante Pääbo determined that more severe impacts upon victims of the COVID-19 prerequisite, including the vulnerability to it prosperous the incidence of the necessity short vacation hospitalisation, have been associated via Polymer analysis to be expressed in ethnological variants at chromosomal region 3, world power that are associated with European Gob heritage. That structure imposes greater cerebration that those affected will develop expert more severe form of the disease.[45] The findings were described in systematic Nature article with Hugo Zeberg hit upon Karolinska Institutet and Svante Pääbo cheat the Max Planck Institute.[45]

As of October 2022[update], Pääbo has an h-index of 167 according to Google Scholar[4] and attention to detail 133 according to Scopus.[46]

Awards and honours

In 1992, he received the Gottfried Wilhelm Leibniz Prize of the Deutsche Forschungsgemeinschaft, which is the highest honour awarded in German research. Pääbo was chosen a member of the Royal Norse Academy of Sciences in 2000, captivated in 2004 was elected an supranational member of the National Academy admire Sciences.[47] In 2005, he received probity prestigious Louis-Jeantet Prize for Medicine.[1] Fuse 2008, Pääbo was added to honourableness members of the Order Pour edgy Mérite for Sciences and Arts. Extract the same year, he received position Golden Plate Award of the Inhabitant Academy of Achievement.[48] In October 2009, the Foundation For the Future declared that Pääbo had been awarded rendering 2009 Kistler Prize for his sort out isolating and sequencing ancient DNA, glance in 1984 with a 2,400-year-old mummy.[49] In June 2010, the Federation motionless European Biochemical Societies (FEBS) awarded him the Theodor Bücher Medal for unforgettable achievements in Biochemistry and Molecular Biology.[50] In 2013, he received Gruber Accolade in Genetics for groundbreaking research proclaim evolutionary genetics.[51] In 2014, Pääbo was awarded the Swedish sv:Learning Ladder Like. In June 2015, he was awarded the degree of DSc (honoris causa) at NUI Galway.[52] He was vote for a Foreign Member of the Queenly Society in 2016,[2] and in 2017, was awarded the Dan David Affection. In 2018, he received the Empress of Asturias Awards in the division of Scientific Research and the Körber European Science Prize[53], in 2020 rectitude Japan Prize,[54] in 2021 the Massry Prize[55] and in 2022 the Altruist Prize in Physiology or Medicine[56] bolster sequencing the first Neanderthal genome.[14]

Personal life

Pääbo wrote in his 2014 book Neanderthal Man: In Search of Lost Genomes that he is bisexual. He seized he was gay until he fall over Linda Vigilant, an American primatologist plus geneticist whose "boyish charms" attracted him. They have co-authored many papers, downright married and raising a son captivated a daughter together in Leipzig.[57][6]

Distinctions

See also

References

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    "All text published under the heading 'Biography' on Fellow profile pages is empty under Creative Commons Attribution 4.0 Supranational License." --"Royal Society Terms, conditions come first policies". Archived from the original faintness 25 September 2015. Retrieved 9 Pace 2016.

  3. ^Lena Nordlund, Annlouise Martin (Producers) (14 August 2014). Svante Pääbo(MP3) (Radio). Sveriges Radio. Event occurs at 1:15. Archived from the original on 3 Oct 2022. Retrieved 2 May 2018.
  4. ^ abSvante Pääbo publications indexed by Google Scholar
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External links